Detalhe da pesquisa
1.
Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell
; 184(2): 370-383.e13, 2021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33333023
2.
The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity.
Cell
; 162(1): 72-83, 2015 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26119340
3.
Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells.
Proc Natl Acad Sci U S A
; 121(4): e2311313121, 2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38241436
4.
Structural basis for the action of the drug trametinib at KSR-bound MEK.
Nature
; 588(7838): 509-514, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32927473
5.
Dabrafenib plus trametinib in patients with relapsed/refractory BRAF V600E mutation-positive hairy cell leukemia.
Blood
; 141(9): 996-1006, 2023 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36108341
6.
Near complete remission of an inoperable pancreatic acinar cell carcinoma after BRAF-/MEK-inhibitor treatment-A case report and review of the literature.
Genes Chromosomes Cancer
; 63(2): e23222, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38340027
7.
Structure and function analysis of a type III preQ1-I riboswitch from Escherichia coli reveals direct metabolite sensing by the Shine-Dalgarno sequence.
J Biol Chem
; 299(10): 105208, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37660906
8.
Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation.
Mol Cancer
; 23(1): 78, 2024 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38643157
9.
Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy.
N Engl J Med
; 384(7): 630-642, 2021 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596357
10.
Multifunctional Photo-Cross-Linking Probes: From Target Protein Searching to Imaging Applications.
Acc Chem Res
; 56(1): 25-36, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36534922
11.
Synergistic effect of adavosertib and fimepinostat on acute myeloid leukemia cells by enhancing the induction of DNA damage.
Invest New Drugs
; 42(1): 70-79, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38085423
12.
Two-year efficacy and safety of relugolix combination therapy in women with endometriosis-associated pain: SPIRIT open-label extension study.
Hum Reprod
; 39(3): 526-537, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38243752
13.
LOGGIC/FIREFLY-2: a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration.
BMC Cancer
; 24(1): 147, 2024 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38291372
14.
Relugolix combination therapy in Black/African American women with symptomatic uterine fibroids: LIBERTY Long-Term Extension study.
Am J Obstet Gynecol
; 230(2): 237.e1-237.e11, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37863160
15.
Response to Dabrafenib Plus Trametinib in a Patient With an Uncommon Activating BRAF Mutation: A First in Non-Small Cell Lung Cancer.
J Natl Compr Canc Netw
; 22(3)2024 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38479107
16.
Comparison of mirabegron and vibegron for clinical efficacy and safety in female patients with overactive bladder: a multicenter prospective randomized crossover trial.
World J Urol
; 42(1): 113, 2024 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38431689
17.
The safety and efficacy of dabrafenib and trametinib in patients with glioma: A systematic review and meta-analysis.
Eur J Clin Pharmacol
; 80(5): 639-656, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38345637
18.
Evaluating relugolix for the treatment of prostate cancer in real-world settings of care: the OPTYX study protocol.
Future Oncol
; 20(12): 727-738, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38488039
19.
Discovery of novel selective phosphodiesterase1 inhibitors for the treatment of acute myelogenous leukemia.
Bioorg Chem
; 144: 107114, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38224637
20.
Population pharmacokinetic/pharmacodynamic modeling of nifekalant injection with varies dosing plan in Chinese volunteers: a randomized, blind, placebo-controlled study.
J Pharmacokinet Pharmacodyn
; 51(1): 77-87, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37566244